Newcastle duo George McGuigan and Adam Radwan, and Gloucester’s Jack Singleton have been called-up as replacements.
They have already joined up with the squad in London for a three-day training camp.
England’s first autumn international is against Argentina on 6 November.
Jones’ side then hosts Japan, New Zealand, and world champions South Africa at Twickenham over consecutive weekends.
England already had a long injury list before these latest withdrawals, with the likes of Saracens lock Maro Itoje, number eight Alex Dombrandt, and wing Anthony Watson all currently sidelined.